Impact of Natural Antioxidant on Liver Function

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Abstract

Objective: This study was designed to investigate the antidiabetic activity of natural antioxidants (kaempferol, apigenin, and alpha-alanine) on liver enzymes in experimentally diabetic rats (Rattus norvegicus).Methods: The rats were divided into five groups (each group contains six male rats); the first group (negative control) injected intraperitoneally with 0.1 ml of normal saline; the second group (positive control) injected intraperitoneally with 100 mg/kg of alloxan, for once only to induce diabetes, after infecting the other groups with D.M. treated daily for 28 days as: the third group treated with 25 mg/kg Keampferol (KF), the fourth group treated with 25 mg/kg Apignine (AP), and the fifth group treated with 25 mg/kg al-alanine (AA).Results: The results indicate that the treatment of experimentally diabetic rats with natural antioxidants caused a significant increase in TG concentration in the third and fourth groups compared with the first and second groups, a significant decrease in the fifth group compared to other groups, and a significant decrease in LDL, HDL, and TC in the third, fourth, and fifth groups compared with the first and second groups. Also, the results showed a significant decrease in ALT and AST in the third, fourth, and fifth groups and in ALP (except for the fourth group) compared with the second group. The results revealed a significant increase in TBIL in the third and fourth groups and a significant decrease in the fifth group compared with the second group, as well as a significant decrease in ALB in the third, fourth, and fifth groups compared with the second group. Conclusion: The present study indicates that there are positive effects of kaempferol, apigenin, and alpha-alanine on the liver function of experimentally diabetic rats.