Evaluation of Serum CYP2C19 Levels in Hypertensive Patients vs. Healthy Controls

الملخص

    Hypertension is a complex condition arising from the interaction of genetic and environmental factors and represents a major global health challenge due to is contribution to cardiovascular morbidity and mortality. The case-control study was performed in Wasit Province, Iraq, between October 2025 and March 2026 to assess the levels of circulating CYP2C19 in patients with hypertension. A total of 80 participants were recruited; 45 patients with clinically confirmed hypertension and 35 healthy controls.  ELISA-based analysis demonstrated significantly elevated serum CYP2C19 levels in hypertensive patients (6.29 ± 0.71 ng/mL) compared with healthy controls (4.17 ± 0.22 ng/mL), with a highly significant difference (p = 0.0001). Gender-based analysis showed no significant differences within controls (p = 0.458) or patients (p = 0.100), yet serum levels were significantly higher in patients than controls for both males (p = 0.01) and females (p = 0.001).In conclusion ,there is  a potential association between increased CYP2C19 expression and pathophysiology of hypertension. Serum CPY2C19 is elevated in hypertensive patients regardless of gender, indicating its potential involvement in disease