HOX-B4 Gene Expression Associated with Stage, Grade, and Invasiveness in Endometrial Carcinoma

الملخص

    Mainly, endometrial carcinoma(EC) was reported as  most common malignancies overall. It primarily affects postmenopausal women. Its develops from endometrium and was categorized into two types based on the development mechanism: responsive and non-responsive to estrogen, with dramatically different gene expression profiles, HOXB4 is an important transcription factor that regulates gene expression and plays a key role in the self-renewal and expansion of hematopoietic stem cells. the study's goal was to to evaluate the relation between HOXB4 gene expression and clinic pathological parameters including stage, grade, endometrial invasion, and lymph node involvement. We wanted to characterize the modifications of tumor benign, malignant and normal cases and evaluate the correlations between the HOX-B4 expression and pathological factors including stages, grades, muscles and lymph nodes invasiveness. Principally, HOX-B4 expression value showed up-regulation inHOX-B4 expression that  a significant differences (P-value < 0.001) between EC patients and healthy control group. These outcomes also show significance differences (P-value< 0.001) between patient group with endometrial benign tumour and the control, as well as a significant differences (P-value<0.001) between patient and those with benign tumors.