The Protective Role of Date Palm Pollen Suspension on Carbon Tetrachloride (CCl4)-induced Reproductive Toxicity in Male Rats

الملخص

Date palm pollen (DPP) is used in traditional medicine and as a dietary supplement. The present study was carried out to investigate the effect of date palm pollen suspension against the toxic effects of carbon tetrachloride (CCL4) on some aspects of reproductive performance in adult male rats. Twenty adult male rats were randomly divided into four equal groups (5 rats/group) and were treated for 63 days as follows: the first group was considered a control group, the second group received date palm pollen suspension orally (0.15 gm/kg B.W) once a day, the third group were treated intraperitoneal (IP)  with 0.5 gm/kg B.W. of  CCL4 mixing with an equal volume of olive oil twice a week, the fourth group was received date palm pollen suspension (0.15 /kg B.W) once a day orally and treated IP with 0.5 gm/kg B.W. of  CCL4 mixing with an equal volume of olive oil twice a week. The result showed that daily oral administration of DPP caused a significant p<0.05 increase in serum testosterone concentration improved semen analysis and an elevated number of sertoli cells, leydig cells and diameter of seminiferous tubules. While the group treated with CCL4 showed a decrease significantly p<0.05 in testosterone, semen analysis and histological measurements. While, the result showed that treatment animals treated with oral administration of DPP in group T3 restore change in testosterone hormones concentration and reproductive parameters which induce by CCL4 to towards normalization. It is therefore concluded that oral administration of DPP promotes reproductive parameters and prevents CCL4 induced reproductive toxicity.