Effect of Splenectomy in thalassemia major patients on some blood parameters, hormones & Blood transfusion frequency

Abstract

To assess the benefit of the elective splenectomy in particular patients cases with thalassemia major. This is a cross sectional study, carried out in Azadi teaching hospital Kirkuk, Iraq, from the period of Jan. 2013 to April 2014. Out of 60 patients 33 (55%) were male and 27(45%) were female, age ranges from 10-20 years with a mean age of 15 years. Out of 60 patients, 37 were splenectomized and 23 were non splenectomized. There was no significant difference in regard of Hb, PCV, serum ferritin, FSH, LH and GH in both sexes between splenectomized and non splenectomized patients, but we found a significant difference only in female FSH conc. between splenectomized and non splenectomized female. in splenectomised patients, blood transfusions decreased significantly, furthermore, most patients receive the lowest number of blood transfusions. In selected thalassemia major patients, we conclude that splenectomy is a safe and helpful surgery.