Microbiological, Histopathological and Epidemiological Assessment of patients with Staphylococcus aureus in Babylon Province: A Cross-Sectional Study

Abstract

Atopic dermatitis (AD) is a chronic skin disease with a wide prevalence, with a rate of 20% in children and 6.3% among adults. (AD) is characterized by dry skin, irritation, and constant, annoying itching, the main cause of which is an imbalance in the immune response and increased secretion of helper T cells of the first type Th1 and the second type Th2. Staphylococcus aureus bacteria are associated with the disease. This study aimed to analyze the microbial content and histological changes associated with atopic dermatitis. The study included recruiting 180 patients who were clinically diagnosed with (AD). Swabs were inoculated from active skin lesions to culture the bacteria and identify the most abundant species. Histological analysis was measured and histological changes were identified. Then, patient data were collected to determine the prevalence of the disease in Babylon Governorate. Statistical analyses were conducted using chi-square and P-value percentages Results: Staphylococcus aureus was the most prevalent (60.25%) at the significance level (P=0.0001) and the prevalence of the disease in females was 52.49% compared to males 47.51% at the significance level (P=0.0001). Histological changes associated with the disease have been identified. Staphylococcus aureus is abundantly associated with patients, confirming the importance of the microbial role in the mechanism and severity of the disease.