The relationship between β-catenin and thyroid function after total thyroidectomy

Abstract

Decreased T3, T4 are one of the major complications following total thyroidectomy that can range in severity from asymptomatic to an acute life-threatening condition. This decrease was accompanied by an increase in the hormone TSH and the study showed a decrease in protein β-catenin after total thyroidectomy. The current study aims to evaluate the changes that occur in T3, T4, TSH and β-catenin in total thyroidectomy patients, with regard to the periods after the operation.Materials and methods included the presence of three groups of patients with different characteristics in terms of times after the total removal of the thyroid gland, and a fourth group is the healthy group, and each group consisted of 30 samples. Patients with cancer, diabetes, blood pressure, and pregnant women were excluded from the study. Results of this study have shown, decreased T3, T4 and β-catenin was different from one group to another, but all three groups were low than the control group, where the first group was lowest, and then the second and third groups. At the same time, the TSH showed opposite results to the thyroid hormones, as it was noted that the first group was higher than the other groups, and the groups after extraction were larger than the control. The study showed a decrease in the function of the thyroid gland after thyroidectomy, and this was accompanied by an increase in thyroid-stimulating hormone and a decrease in β-catenin in the studied groups after thyroidectomy.