Genetic and Biochemical Association to Renal Failure
Keywords:
Hepatitis A virus cellular receptor 1 (HAVCR1), Apolipoprotein L1 (APOL1), Single nucleotide polymorphisms (SNPs), Genotyping and allele frequencyAbstract
This study aims to valuate SNPs in APOL1 and HAVCR1 genes and levels of serum biomarkers in renal failure (RF) patients with acutely kidney injury (AKI) and chronically kidney disease (CKD). A total of 60 RF-diseased (30 AKI and 30 CKD) and 30 healthy control (HC) individuals, were subjected to sampling of venous blood that tested molecularly by PCR serologically by ELISA to measurement KIM-1, suPAR, TNFR1 and TNFR2. Molecularly, the levels and risk of genotyping frequency for CG in APOL1 rs136161 were higher in AKI and CKD patients than healthy ones. Additionally, RF patients showed a lower frequency of C allele and higher risk of G. For HAVCR1 rs6555820 C>A, polymorphism and harm effects of CA and AA genotypes in RF patients were higher; while, frequency and risk of C was lowered and A allele was elevated in RF patents. Significantly, gradual increases in serum KIM-1, suPAR, TNFR1, and TNFR2 were reported markedly in CKD followed by AKI when compared to HC.
