Assessment of some Hormone Concentration in Men with Schizophrenia in Thi-Qar Province/Iraq

Abstract

Schizophrenia is a complex disease with a heterogeneous array of symptoms, including positive symptoms such as delusions and hallucinations, negative symptoms such as social withdrawal, and cognitive symptoms such as dysfunction in cognitive processes and functions.. A study was conducted on a patient group of 100 people and a control group of 10 healthy people to investigate the relationship between schizophrenia and its effects on certain hormones from the anterior pituitary lobe, thyroid hormones, and sex hormones. The working methods were followed according to the number (kits) used in measuring hormones. The results showed a significant decrease in the concentrations of both luteinizing hormone (LH) and prolactin hormone, while there was no significant difference in the concentration of follicle-stimulating hormone (FSH). There was also a significant increase in the concentrations of triiodothyronine (T3) and thyroxine (T4), and a significant decrease in the concentration of thyroid-stimulating hormone (TSH). Furthermore, there was a significant increase in the concentration of testosterone and a significant decrease in the concentrations of both estrogen and progesterone in patients with schizophrenia when compared to the control group (healthy men) at a probability level of P≤0.05. The study showed a negative effect of schizophrenia on the hormonal parameters studied.