Antiurolithiatic Activity of Corn Oil on Ethylene Glycol-induced Renal Stone in Male Albino Rats

Abstract

     This study evaluated the effects of ethylene glycol (EG) and corn oil (CO) in male albino rats. Twenty-eight male albino rats (Rattus norvegicus) were randomly assigned into four equal groups (n = 7): (1) control group fed a basal diet with tap water ad libitum; (2) EG group fed a basal diet with drinking water containing 0.75% EG ad libitum; (3) EG + CO group fed a basal diet with 0.75% EG in drinking water ad libitum and received corn oil (0.3 mL/BW) orally by gavage; and (4) CO group fed a basal diet with tap water ad libitum and received CO by gavage. EG was administered for 28 days. The CO was given from day 14 to day 28. Results showed that EG significantly increased food intake during the third week and increased left kidney weight. EG caused non-significant increases in body weight, right kidney weight, and the weights of liver and heart. It also produced non-significant increases in red blood cells count, blood urea, and malondialdehyde (MDA). In contrast, EG reduced blood creatinine levels. Overall, the study suggests that CO is highly digestible and provides energy and essential fatty acids.