Mrs Evaluation of the Role of Gum Arabic Extract on Renal Damage Induced by Oral Bisphenol A Administration in White Rats

Abstract

In the current review, we explored the impact of Gum arabic (GA) against Bisphenol A (BPA)- prompted nephrotoxicity in male albino rats. Thirty-five adult male albino rats were divided into five groups: group (1) served as a control, group (2) rats received 8 mg/ kg of GA extract, group (3) received BPA 50 mg / kg b.wt. by oral gavage, group (4) consists of rats received first GA extract + BPA,  and finally group (5) consists of rats received first BPA + GA extract. Urea, Creatinine, Superoxide dismutase (SOD) glutathione (GSH), and malondialdehyde (MDA) were assayed, in addition to histological study. The results of this study showed that there was a significant increase in the levels of all urea, Creatinine, and MDA, and a significant decrease in the levels of both GSH and SOD in the third group exposed to BPS, while there was a significant decrease in all of urea, Creatinine, and MDA, and a significant increase in the level of antioxidants GSH, SOD in the fourth and fifth groups Which was dosed with GA extract and BPS. Histopathological changes of kidney were observed in third group (treated with BPA) and fourth group (BPA + GA treated) as compared to control group. This study demonstrated the antioxidant effect of GA and against BPS -induced renal injury.